How ionbench can help you to improve your LC/MS performance?
LC / MS performance: It makes sense for a mass spec user to minimise the void volume between the column and the MS Source. This dead volume can be the cause of the chromatography peak tailing. See the Spectrogram below: The spectrogram B is a standard configuration, void volume of 50μL Analysis of two couples of isobaric (250 and 264 m/z) substrate and metabolites performed on the Agilent 1290 Infinity UHPLC / Agilent 6460). Mobile phase: ammoniumformate 20mM pH 9 buffer and acetonitrile. Elution mode: 15%-35% of organic modifier in 3 min at 600_L/min. Injection volume: 2μL. Using the same ...
Source: labmate-online.com