Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis
Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis. The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of V...
Source: news-medical.net