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Abstract The K -sparing diuretic amiloride elicits anticancer activities in multiple animal models. During our recent medicinal chemistry campaign aiming to identify amiloride analogs with improved properties for potential use in cancer, we discovered novel 6-(hetero)aryl-substituted amiloride and 5-(N,N-hexamethylene)amiloride (HMA) analogs with up to 100-fold higher potencies than the parent compounds against urokinase plasminogen activator (uPA), one of amiloride's putative anticancer targets, and no diuretic or antikaliuretic effects. Here, we report the systematic evaluation of structure...

Share this article Share this article Catheter Market has witnessed strong growth owing to the huge prevalence of cardiovascular diseases, coupled with the advancement of unique-feature enhanced cardiovascular catheters. Chronic disorders such as cardiovascular, neurology, and urology disorders have become the most imperative cause of mortality and morbidity across the globe, during the last three decades. JERSEY CITY, N.J., Feb. 8, 2021 /PRNewswire/ -- Verified Market Research recently published a report, "Catheter Market" By Type (Cardiovascular Catheters, Urology Catheters, Intravenous Cat...

Share this article Share this article ResearchAndMarkets.com's offering. The global metabolomics market size is projected to reach USD 4.1 billion by 2025 from USD 1.9 billion in 2020, at a CAGR of 13.4% during the forecast period. The major factors driving the growth of this market are the growing R&D expenditure in the pharmaceutical & biopharmaceutical industry, growing demand for personalized medicine, and increasing use of metabolomics in toxicology testing are driving the growth of the global metabolomics industry. However, issues related to data examination & data processing in metab...