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New Approach Allows Researchers To Hit "Undruggable" Cancer Target

A protein degrader shows potential in targeting STAT5, a protein involved in leukemia and other forms of cancer. For decades, researchers have been interested in targeting the protein STAT5 in the fight against cancer. However, despite extensive efforts, STAT5 was eventually considered "undruggable ....

United States , Hoda Metwally , Shaomeng Wang , Renqi Xu , Atsunori Kaneshige , Donna Mceachern , Femi Wang , Meilin Wang , Yu Wang , Duxin Sun , Jenniferl Meagher , Wei Jiang , Jeannea Stuckey , Proteovant Roivant , Longchuan Bai , Hui Jiang , Pauld Kirchhoff , Bo Wen , Lijie Zhao , Michigan Technology Tri , University Of Michigan , Us Department Of Energy , Rogel Cancer Center Shared Resources , Wang Lab Michigan Medicine , National Cancer Institute , University Of Michigan Rogel Cancer Center ,