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Adaptive platform trial shows promise for finding new glioblastoma therapies

An innovative phase 2 clinical trial led by Dana-Farber Cancer Institute in collaboration with 10 major brain tumor centers around the country and designed to find new potential treatments for glioblastoma has reported initial results in the Journal of Clinical Oncology. While none of the three therapeutics tested so far improved overall survival of patients, this adaptive platform trial, the first of its kind in neuro-oncology, has the potential to rapidly and efficiently identify therapies that benefit patients. ....

United States , Dana Farber Cancer Institute , Danielle Ellis , Patrick Wen , Keith Ligon , Rifaquat Rahman , Eudocia Quant Lee , Brian Alexander , Isabel Arrillaga , Division Of Neuropathology At Brigham , Study Co , Study Co First Author , Radiation Oncologist , Dana Farber Cancer , Individualized Screening Trial , Innovative Glioblastoma Therapy , Lorenzo Trippa , Bayesian Adaptive Randomization , Isabel Arrillaga Romany , Massachusetts General Hospital , Clinical Trial , Brain Tumor , Neuro Oncology ,

Research team leads adaptive, efficient multi-arm phase 2 clinical trial for glioblastoma

Research team leads adaptive, efficient multi-arm phase 2 clinical trial for glioblastoma
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Dana Farber Cancer Institute , United States , Rifaquat Rahman , Keith Ligon , Brian Alexander , Patrick Wen , Eudocia Quant Lee , Isabel Arrillaga , Division Of Neuropathology At Brigham , Individualized Screening Trial , Innovative Glioblastoma Therapy , Lorenzo Trippa , Bayesian Adaptive Randomization , Isabel Arrillaga Romany , Massachusetts General Hospital , Inaugural Results , Clinical Oncology ,

Dana-Farber leads adaptive, efficient multi-a

An innovative phase 2 clinical trial led by Dana-Farber Cancer Institute in collaboration with 10 major brain tumor centers around the country and designed to find new potential treatments for glioblastoma has reported initial results in the Journal of Clinical Oncology. While none of the three therapeutics tested so far improved overall survival of patients, this adaptive platform trial, the first of its kind in neuro-oncology, has the potential to rapidly and efficiently identify therapies that benefit patients. ....

United States , Dana Farber Cancer Institute , Isabel Arrillaga , Nicole Oliverio , Keith Ligon , Bristol Myers Squibb Celgene , Eudocia Quant Lee , Patrick Wen , Rifaquat Rahman , Brian Alexander , Eli Lilly , Celgene Corporation , Puma Biotechnology Inc , National Brain Tumor Society , Cancer Center , Burroughs Wellcome Fund , Division Of Neuropathology At Brigham , Harvard Medical School , Blood Disorders Center , Dana Farber Brigham Cancer Center , Individualized Screening Trial , Innovative Glioblastoma Therapy , Lorenzo Trippa , Bayesian Adaptive Randomization , Isabel Arrillaga Romany , Massachusetts General Hospital ,