Yes, there was once a Lyme Disease vaccine, and it was pulled from the market due to "poor sales" after seeming to generate symptoms that mimicked the disease
Twenty five years ago there was a vaccine marketed for Lyme disease called LYMErix, by SmithKline Beecham (later became GSK), and was approved by the FDA, but pulled from market just 4 years [...]
Source: naturalnews.com