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Significant Milestone Reached In First NZ CAR T-cell Trial As Preparations Made For Larger Phase 2 Registration Trial

The goal of CAR T-cell cancer therapy becoming a standard of care in New Zealand is another step closer with patient enrolment completed and a total of 30 patients treated within the Malaghan Institute’s ENABLE phase 1 safety trial, says Malaghan . ....

New Zealand General , New Zealand , United States , Robert Weinkove , American Society Of Hematology , Maurice Wilkins Centre , Wellington Zhaotai Therapies , Malaghan Institute Clinical , Malaghan Institute Of Medical Research , Malaghan Institute , Hunan Zhaotai Medical Group Changsha , Thompson Family Foundation , Malaghan Institute Wellington , Health Research Council , Zealand Ministry Of Business , Significant Milestone Reached In First , Trial Monday , Joint Press , Malaghan Institute Clinical Director Dr Robert , American Society , Wellington Zhaotai Therapies Limited , Bridgewest Ventures , Blood Cancer New Zealand , Maurice Wilkins , Zhaotai Therapies Limited , New Zealand Registered ,

Third-generation anti-CD19 CAR T-cells demons

<ul>
<li>Adding a new CAR co-stimulatory domain (TLR2) to a conventional CD28-costimulated anti-CD19 CAR T-cell reduces cytokine release syndrome- and neurotoxicity-associated cytokines.</li>
<li>25 patients with relapsed or refractory B-cell non-Hodgkin lymphomas received CD28/TLR2 co-stimulated anti-CD19 CAR T-cells in a phase 1 dose escalation and expansion trial.</li>
<li>No severe CRS and no ICANS neurotoxicity of any grade occurred. Complete responses were seen at doses from 5 × 10<sup>4</sup> to 1 × 10<sup>6</sup> cells/kg.</li>
<li>Outpatient therapy and automated manufacture have been established in preparation for a phase 2 trial.</li>
</ul>
....

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'PH 1 data from a CD19-specific third generation CAR T cell study supports use of BioOra's automated manufacture'

'PH 1 data from a CD19-specific third generation CAR T cell study supports use of BioOra's automated manufacture'
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New Zealand , United States , San Diego , Rob Weinkove , American Society Of Hematology , Malaghan Institute Of Medical Research , Malaghan Institute , Wellington Zhaotai Therapies Limited , Malaghan Institute Clinical , Medical Research , American Society , Annual Meeting , Clinical Director , Principal Investigator , Carl June , Randi Grant ,

3Rd Gen Anti-CD19 CAR T-Cells Demonstrate Efficacy Without Neurotoxicity In B-Cell Lymphoma Phase 1 Clinical Trial

3Rd Gen Anti-CD19 CAR T-Cells Demonstrate Efficacy Without Neurotoxicity In B-Cell Lymphoma Phase 1 Clinical Trial
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San Diego , United States , New Zealand , Gail Marshall , Peter Lai , Robert Weinkove , Malaghan Institute Clinical , Malaghan Institute , Hunan Zhaotai Medical Group , Wellington Zhaotai Therapies , Malaghan Institute Of Medical Research , Wellington Zhaotai Therapies Limited Executive Director , American Society Of Hematology , Guangzhou Institute Of Biomedicine , Medical Research , Wellington Zhaotai Therapies Limited , American Society , Annual Meeting , Malaghan Institute Clinical Director , Principal Investigator Dr Robert , Guangzhou Institute , Hunan Zhaotai Medical , Wellington Zhaotai Therapies Limited Executive , Professor Carl June ,

Third Generation CAR T Cell Study Supports Use Of BioOra's Automated Manufacture For Phase 2 Trial

BioOra together with its founding partner, the Malaghan Institute of Medical Research, announced clinical results from the ENABLE phase 1 clinical trial at the 65th American Society of Hematology (ASH) Annual Meeting in San Diego. ....

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