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Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project


Leducq Foundation provides $7 million to support Cardiac Splicing as a Therapeutic Target project
Diverse messenger RNAs are produced in cells by “alternative splicing.” The Leducq Foundation is now supporting a transatlantic network dedicated to investigating this process in heart muscle cells and how changes in this process contribute to disease. Professor Michael Gotthardt of the MDC and Professor Leslie Leinwand of the University of Colorado Boulder are coordinating the project.
Despite advances in prevention and therapy, cardiovascular diseases are still one of the leading causes of death worldwide. Scientists have only recently begun to understand the key role of alternative splicing - the stitching together of messenger RNA during gene transcription - in cardiovascular diseases. The Leducq Foundation is providing 7 million U.S. dollars over the next five years to support the Cardiac Splicing as a Therapeutic Target (CASTT) project, which is comprised of six E ....

United States , France General , Max Delbr , Emily Henderson , Jean Leducq , Benjamin Meder , Maria Carmo Fonseca , Michael Gotthardt , Leslie Leinwand , Lars Steinmetz , Euan Ashley , University Of Lisbon , Helmholtz Association , University Of Colorado Boulder , Biofrontiers Institute At University Of Colorado Boulder , Leducq Foundation , Stanford University , Heidelberg University Hospital , Professor Leslie Leinwand , Colorado Boulder , Cardiac Splicing , Therapeutic Target , Molecular Medicine , North American Coordinator , Professor Euan Ashley , Professor Maria Carmo Fonseca ,