New drug reveals a key mechanism to overcome resistance to protein degraders
Protein degraders offer a novel approach to targeting undruggable diseases by hijacking the cell's degradation machinery.
Source: newswise.com
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Dimerized Neuropeptide Discovery inspired by Nature
Mar 12 2021 Read 412 Times In a recent study led by MedUni Vienna and the University of Vienna, researchers demonstrated that dimerized (a combination of two identical or different molecules) and therefore significantly larger versions of human neuropeptides oxytocin and vasopressin are still able to activate their receptors without forfeiting too much of their efficacy. Such new constructs provide several opportunities to optimise the efficacy of these neuropeptides for therapeutic application. Oxytocin/vasopressin receptors are typical examples of so-called G protein-coupled receptors – t...
Source: labmate-online.com