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Venom's usually the stuff of nightmares. Animals that wield it send instinctive shivers down our spines. But scientists are teasing out useful purposes for these powerful substances that (sometimes incidentally) can cause us so much pain and damage. Recently we've seen developments from several types of venoms, from bee venom as a cancer treatment to using platypus venom for diabetes.   A team of researchers has developed the next venom-based medical advancement: a fast-acting "super glue" that stops bleeding in under a minute. While synthetic adhesives can be easier to manipulate, their d...

Mar 12 2021 Read 412 Times In a recent study led by MedUni Vienna and the University of Vienna, researchers demonstrated that dimerized (a combination of two identical or different molecules) and therefore significantly larger versions of human neuropeptides oxytocin and vasopressin are still able to activate their receptors without forfeiting too much of their efficacy. Such new constructs provide several opportunities to optimise the efficacy of these neuropeptides for therapeutic application. Oxytocin/vasopressin receptors are typical examples of so-called G protein-coupled receptors – t...

Scientists present new outlook on latest trends in peptide drug discovery and development Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis. In the recent issue of " Nature Reviews Drug Discovery", a team of Austrian and Australian scientists led by medicinal chemist Markus Muttenthaler of the University of Vienna present an outlook...

There are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases. In

 E-Mail Dimerization (Note: combination of two identical or different molecules) of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules. In a recent study, an international research team led by MedUni Vienna and the University of Vienna demonstrated that dimerized and therefore significantly larger versions of oxytocin and vasopressin are still able to activate their receptors. Such new constructs provide several opportunities to optimize the efficacy of these neuropeptides for therapeutic application. The researchers were inspired for this approach ...