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"Mass Spectrometry Imaging of Lipids" by Shane R. Ellis and Jens Soltwisch

Mass spectrometry imaging (MSI) is a label-free imaging technique capable of simultaneously imaging hundreds of molecular species and is widely applied to imaging lipids throughout various biological systems such as tissues and increasingly, single cells. Given the rapidly growing popularity of lipid MSI, this book chapter aims to provide a comprehensive introduction to the field for both new and experienced researchers alike. The chapter begins by outlining critical sample preparation requirements for imaging lipids using MSI before describing the common desorption/ionization techniques for MSI, including their spatial resolution and ability to detect various lipid species. The capabilities of each desorption/ionization approach are exemplified by highlighting selected biological applications of each approach. The benefits of ion mobility and chemical derivatisation strategies are then discussed before outlining strategies for the quantification of lipids with MSI. Finally, we describ ....

Mass Spectrometry Imaging ,

Researchers create new spatial omics method

Researchers create new spatial omics method
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Uppsala Lan , Marco Vicari , Researchers At Uppsala University , Royal Institute Of Technology , Stockholm University , Nature Biotechnology , Uppsala University , Per Andr , Mass Spectrometry Imaging ,

Waters boosts resolution and scan speed of SELECT SERIES MRT

Waters Corporation (NYSE:WAT) has announced new updates to its SELECT SERIES™ MRT System that increases its specificity and utility for UPLC-MS/MS metabolomics and drug discovery applications and for mass spectrometry imaging experiments. The MRT System now offers 50% higher resolution, making it capable of 300,000 FWHM resolution, a 3X faster scan rate, and parts-per-billion mass accuracy. ....

Stephen Smith , Simona Francese , University Centre For Mass Spectrometry Imaging , Discovery Development , Sheffield Hallam University , Waters Corporation , Product News , Vice President , Nature Scientific Reports , Mass Spectrometry Imaging , Waters Boosts Resolution And Triples Scan Speed Of Select Series Mrt For Metabolomics Ms Imaging , Elect Series Mrt ,