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Approaches to Treatment Decision-Making and Sequencing for HR+, HER2- Metastatic Breast Cancer

The doctors recommend using endocrine therapy-based options first-line when possible, before considering chemotherapy or antibody-drug conjugates, in order to preserve quality of life; they note exceptions could include patients with rapid progression or visceral crisis where immediate chemotherapy may be warranted, and that determining optimal sequencing requires understanding the safety profiles and efficacy data for the available regimens. ....

Emerging Therapies , Breast Cancer , Treatment Decision Making , Metastatic Breast Cancer , Breast Cancer Treatments , Breast Cancer Therapies , Metastatic Breast Cancer Treatments ,

The TROPION-Breast01 Trial: Datopotamab Deruxtecan in HR+, HER2- Breast Cancer

The TROPION-Breast01 trial studied the antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) in previously treated HR+, HER2- breast cancer patients and showed improved progression-free survival to 7 months compared to 4.5 months with standard chemotherapy, with less high grade toxicity observed with Dato-DXd. ....

Datopotamab Deruxtecan , Emerging Therapies , Breast Cancer , Metastatic Breast Cancer , Breast Cancer Treatments , Breast Cancer Therapies , Metastatic Breast Cancer Treatments ,

Kansas City Chiefs parade shooting timeline

Sister station KMBC captured the moment shots rang out. Viewer discretion is advised. ....

Kansas City , United States , Mitch Holthus , Matt Flener , Glen Jennings , Lara Moritz , Investigative Reporter , City Chiefs , Kansas City Super Bowl , Union Station , Wednesday The , Chiefs Kingdom , Super Bowl , Union Station Two , Liberty Memorial , Kansas City ,

Elacestrant: Treatment Considerations, Including Dosing and Compliance

Experts explore treatment considerations when treating patients with metastatic breast cancer with elacestrant, including dosing, patient selection, adherence, and treatment duration. Participants also discuss dose modifications, adherence concerns, and how they determine treatment failure. ....

William Gradishar , Mabel Mardones , Rena Callahan , Gregory Vidal , Peer Exchange , Oral Serd , Metastatic Breast Cancer , Therapeutic Advances , Panel Discussion , Her Positive , Her2 Negative , Selective Estrogen Receptor Degrader , Endocrine Therapy , Targeted Therapy , Treatment Developments , Medical Oncology , Breast Oncology , Breast Cancer , Clinical Guidelines , Fda Label , Nccn Guidelines , Esr1 Mutations , Treatment Resistance , Moral Therapy , Disease Progression , Patient Profiles ,

Patrick, Brittany Mahomes visit hospital to see children shot at Chiefs rally

Patrick and Brittany Mahomes visited young girls who are hospitalized after being shot during the Kansas City Chiefs’ Super Bowl rally. ....

Patrick Mahomes , Patrick Brittany Mahomes , Katie Martinez , Lisa Lopez Galvan , Super Bowl , Mercy Hospital , Dov Kleiman , Brittany Mahomes , Kansas City Chiefs Super Bowl , Brittany Mahomes , Super Bowl Parade , Children 39s Mercy Hospital , Keyes Family , Kansas City Chiefs ,