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Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.
Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage A paper published today in Nature shows how chemicals in the areas surrounding tumors—known as the tumor microenvironment—subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. The study was conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, led by Pitt associate professor of immunology Greg Delgoffe. By disrupting the effect of the tumor microenvironment on immune cells in mi...
E-Mail IMAGE: Cancer evades the immune system by "feeding " the T cells that protect the tumor and "starving " the T cells that would attack. view more Credit: UPMC, created with BioRender.com PITTSBURGH, Feb. 15, 2021 - A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. The study was conducted by a team of scientists at UPMC Hillman Cancer Center and the University of...