Dual Checkpoint Blockade No Help in PD-L1-High NSCLC
email article Adding a CTLA-4 checkpoint inhibitor to pembrolizumab (Keytruda) failed to improve survival in previously untreated patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression levels, a phase III trial found. In KEYNOTE 598, the PD-1 checkpoint inhibitor pembrolizumab plus ipilimumab (Yervoy) yielded a median overall survival (OS) of 21.4 months in patients with a tumor proportion score (TPS) of 50% or greater, as compared to 21.9 months with pembrolizumab plus placebo (HR 1.08, 95% CI 0.85-1.37, P=0.74), reported Michael Boyer, MBBS, PhD, of the...