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Mice having a keratinocyte-specific deletion of the receptor for the cytokine TWEAK, Fn14, display reduced skin inflammation upon chemical induction, including decreased epidermal hyperplasia and less expression of psoriasis signature genes. Based on this finding and transcriptomic analysis of human keratinocytes, Michael Croft, PhD, and his team have shown TWEAK works together with the known cytokines TNF or IL-17 in provoking inflammation in psoriasis. The study shows targeting TWEAK could offer an alternative approach to treating the disease.

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes.

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies-;and for many, the relief is temporary.

Date Time “Plastic Action Day” in World Man and Biosphere Reserve Cu Lao Cham – Hoi An Soon after being recognised as a UNESCO World Biosphere Reserve in 2009, Cu Lao Cham – Hoi An has become a pioneer in eliminating plastic bags and other single-use plastic movements. Despite this success, a massive amount of waste, the lack of awareness and inefficient trash management continue to present a plastic challenge for the Reserve. In this regard, UNESCO launched the programme of Youth Initiative for an Ocean without Plastic under the support of Coca-Cola Foundation to contribute to the ef...

Died: April 8, 2021. PETER Terson, who has died aged 89 after suffering from Parkinson’s disease, was a playwright who brought to the stage and screen authentic representations of working-class culture inspired by his childhood in the industrial north-east of England. His first major success, Zigger Zagger, staged at the Jeanetta Cochrane Theatre, London, by the National Youth Theatre in 1967, opened a window on the world of football hooliganism. The 90-strong cast stood in a specially constructed stand, singing their irreverent comments and chants such as “Zigger zagger! Oi! Oi! ...