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The timing and dosage of DNA-damaging drugs determine whether cancer cells die or enter senescence, according to a study from the MIT Koch Institute lab of Michael Yaffe. The work suggests clinical implications for combining chemotherapy with MEK inhibitors.
Kinases are essential for cell signaling. A new study matches hundreds of kinases to their targets, enabling a deeper understanding of biological processes.
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One of the most important classes of human enzymes are protein kinases -; signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.
A new atlas maps more than 300 protein kinases found in human cells and identifies which types of protein substrates they target
A new atlas maps more than 300 protein kinases found in human cells, and identifies which types of protein substrates they target. The atlas could help scientists understand what happens when cells become cancerous or are treated with specific drugs.