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"Functional mass spectrometry imaging maps phospholipase-A2 enzyme acti" by Xiwei Fan, Reuben S.E. Young et al.

Background: Enzymes are central components of many physiological processes, and changes in enzyme activity are linked to numerous disease states, including osteoarthritis (OA). Assessing changes in enzyme function can be challenging because of difficulties in separating affected tissue areas that result in the homogenisation of healthy and diseased cells. Direct correlation between spatially-resolved enzyme distribution(s) and diseased cells/tissues can thus lead to advances in our understanding of OA pathophysiology. Herein, we present a method that uses mass spectrometry imaging (MSI) to visualise the distribution of lipase enzymes and their downstream lipid products in fresh bone and cartilage tissue sections. Immunohistostaining of adjacent tissue sections was then used to identify OA cells/tissues, which were then statistically correlated with molecular-level images. Methods: MSI was used to image lipase enzymes, their substrates, and their metabolic products to validate enzymatic ....

Enzyme Dynamics , Aldi Msi ,

Leveraging Endoscopic Ultrasound in Pancreatic Cancer: Pancreatic Cancer Ablation and Immune Modulation

In this sixth episode of OncChats: Leveraging Endoscopic Ultrasound in Pancreatic Cancer, Toufic A. Kachaamy, MD, Madappa Kundranda, MD, PhD, and Tamas A. Gonda, MD, briefly discuss pancreatic cancer ablation and immune modulation. ....

Tamasa Gonda , Toufica Kachaamy , Madappa Kundranda , Banner Md Anderson Cancer Center , Leveraging Endoscopic Ultrasound , Pancreatic Cancer , Cancer Center , Endoscopic Ultrasound , Pancreatic Cancer Ablation , Immune Modulation , City Of Hope , Nyu Langone , Radiofrequency Ablation ,

Microdevice could make brain tumor treatment easier

Revolutionary microdevice developed by Brigham and Women s Hospital researchers could help physicians pick the right treatments for glioma tumors. ....

Pierpaolo Peruzzi , Boston Based Brigham , Science Translational , Cancer Treatments , Cancer Therapies , Ancer Device , Cancer Drugs , Tumor Drug ,