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The music mogul, 63, looked unrecognisable as he showed off his incredibly smooth visage in the clip as he marked One Direction reaching one billion streams on Spotify.
Calvin Harris risked the ire of Simon Cowell on Thursday after he poked fun at the music mogul's 'cosmetic work'.
The author, 73, revealed he fought the illness last year but is now in remission after an NHS op and chemo.
The music mogul previously baffled viewers with his noticeably different complexion, despite denying he has had a facelift.
The music mogul, 63, is back on the judging panel alongside Amanda Holden, Alesha Dixon and newcomer Bruno Tonioli.