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An analysis of 2 population-based cohorts suggests coronary artery calcium scores added to traditional risk-based models showed better discrimination than polygenic risk scores for CHD risk prediction.
Authors say findings show the need to test the accuracy of oximeters across diverse populations.
Data show CV risk discrimination improved when adding a coronary artery calcium score to a CHD prediction model based on traditional risk factors; however, there were no changes when adding a polygenic risk score.The analysis of two large cohorts of middle-age and older adults with long-term follow-up — all with available genetic data and coronary CT scans — addresses a key knowledge
The combination of the two scores also had no additive predictive power compared with the coronary artery calcium score alone, the researchers found.
Data from a secondary analysis showed a smaller decrease in oxygen saturation in Black patients compared with White patients with OSA.