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By David L. Chandler, Massachusetts Institute of Technology May 16, 2024

This illustration shows a 3D printed heart ventricle engineered with fiber-infused ink. Credit: Harvard SEAS By Kat J. McAlpine / SEAS Communications Over the last decade, advances in 3D printing have unlocked new possibilities for bioengineers to build heart tissues and structures. Their goals include creating better in vitro platforms for discovering new therapeutics for heart disease, the leading cause of death in the United States, responsible for about one in every five deaths nationally, and using 3D-printed cardiac tissues to evaluate which treatments might work best in individual patie...

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Over the last decade, advances in 3D printing have unlocked new possibilities for bioengineers to build heart tissues and structures.

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) report the development of a new hydrogel ink infused with gelatin fibers that enables 3D printing of a functional heart ventricle that mimics beating like a human heart. They discovered the fiber-infused gel (FIG) ink allows heart muscle cells printed in the shape of a ventricle to align and beat in coordination like a human heart chamber.