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New findings by UT Southwestern researchers help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

Ion channel conserved in coronaviruses a potential new drug target for COVID therapeutics Much of the research on the coronavirus disease 2019 (COVID-19) therapeutics has been focused on essential structures such as the virus-encoded spike protein, main proteases, as well as ribonucleic acid (RNA) polymerase proteins. Obtaining high-resolution analyses of these structures provides a mechanical insight into their function and assists in using these structures as targets in the development of both vaccines and anti-viral therapeutics. A better understanding of these structures will also allow s...

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H. Hartwell the 2001 Nobel Prize in Physiology or Medicine. A study led by Óscar Fernández-Capetill...

Credit: CNIO Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H. Hartwell the 2001 Nobel Prize in Physiology or Medicine. A study led by Óscar Fernández-Capetillo, Head of the Genomic Instability Group at the Spanish National Cancer Resear...