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Cureus | Multidrug-Resistant Musculoskeletal Tuberculosis: An Aggressive Clinical, Radiological and Molecular Confirmation With Genotypic Drug Susceptibility Testing Approach

Introduction

Increasing evidence suggests that musculoskeletal tuberculosis (MSTB) causes significant morbidity due to the late presentation of symptoms and lack of accurate diagnosis. We aimed to assess the utility of two modalities, viz. radiology and molecular methods, in the early diagnosis of MSTB. Also, the rate of resistance to two basic first-line antitubercular drugs in musculoskeletal TB cases among clinically suspected patients was analyzed.

Methods

Samples from 119 patients with clinical suspicion of musculoskeletal TB were included. A radiological workup of patient and smear microscopy, mycobacterial culture, real-time multiplex polymerase chain reaction (PCR), cartridge based nucleic acid amplification test (CBNAAT), and line probe assay (LPA) of samples were carried out.

Results

Maximum positivity (69.74%) was observed by real-time multiplex, followed by CBNAAT and LPA (68.9%), mycobacterial culture (40.3%), and smear microscopy (19.3%). One additional advantage of using multiplex PCR was the detection of non-tuberculous mycobacteria (NTM) isolate. Forty-five strains (54.9%) on LPA were susceptible to rifampicin and isoniazid, eight (9.8%) were rifampicin mono-resistant, seven (8.5%) were isoniazid (INH) mono-resistant, and 22 (26.8%) were multidrug resistant.

Conclusions

MSTB diagnosis can be expedited by the combination of radiology and molecular methods. The positivity rate escalates, turnaround time improves, and the additional advantage of detection of drug resistance is added when this algorithm is included for clinching the diagnosis of MSTB.

Germany , United-states , India , Nehren , Rheinland-pfalz , Franklin-lakes , Hain-lifescience , India-ltd , Himalayan-institute-of-medical-sciences , Research-committee , Microsoft , North-india

Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study

Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

South-africa , Germany , United-states , Johannesburg , Gauteng , Nehren , Rheinland-pfalz , Mtbdrsl-hain-lifescience , National-department-of-health , University-of-witwatersrand-johannesburg , Human-research-ethics-committee , Cepheid

Consultation for German tram-train network launched

A planning consultation is underway for an electrified line connecting cities in Baden-Württemberg to form a tram-train network.

Germany , Sigmaringen , Baden-wüberg , Reutlingen , Nehren , Rheinland-pfalz , Gomaringen , Stadtbahn-neckar , Regional-stadtbahn-neckar-alb ,

Live-Blog | 22 Bürgermeister für die Stadtbahn, Statistik vor dem Wahlwochenende

Live-Blog | 22 Bürgermeister für die Stadtbahn, Statistik vor dem Wahlwochenende
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Metzingen , Niedersachsen , Germany , Mossingen , Baden-wüberg , Landkreis-tubingen , Neckar-odenwald-kreis , Burladingen , Star-zach , Gomaringen , Land-baden-wurttemberg , Rubgarten

Beim Überholen geschnitten: Jugendliche schwer verletzt

Beim Überholen geschnitten: Jugendliche schwer verletzt
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Nehren , Rheinland-pfalz , Germany , Gomaringen-towards-nehren ,

Fair-Play in doppelter Ausführung

Fair-Play in doppelter Ausführung
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Ergenzingen , Baden-wüberg , Germany , Hirschau , Bayern , Aspach , Mossingen , Nehren , Rheinland-pfalz , Rainer-horrmann , John-christopher , Jahn-regensburg

Maßnahmen gegen Starkregen: Sandsäcke zum Schutz

Maßnahmen gegen Starkregen: Sandsäcke zum Schutz
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Mossingen , Baden-wüberg , Germany , Nehren , Rheinland-pfalz , Town-council , District-administration , S-district-administration , Strong-rain , Rainstorms-end-june , Water-management

Schnelleres Netz für den Kreis Tübingen

Schnelleres Netz für den Kreis Tübingen
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Mossingen , Baden-wüberg , Germany , Nehren , Rheinland-pfalz , Gomaringen , Faster-network , Group-for-middlea-expansion , Health-of-local-residents , Data-traffic , Growth-rates

Boyens Medien: Family Dogs on Tour

Boyens Medien: Family Dogs on Tour
boyens-medien.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from boyens-medien.de Daily Mail and Mail on Sunday newspapers.

Lohe-rickelshof , Schleswig-holstein , Germany , Nehren , Rheinland-pfalz , Heiko-hoxha , Family-dogs , Tour-lohe-rickelshof , Republic-has , Comfort-leave , All-vehicles-heiko-hoxha

SV Nehren: „Würgetor" zum späten Punktgewinn

SV Nehren: „Würgetor" zum späten Punktgewinn
tagblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagblatt.de Daily Mail and Mail on Sunday newspapers.

Nehren , Rheinland-pfalz , Germany , Dot-gain , Eye-level , Standard-situation , Counter-occasions , Nachspiel-time , Inside-linebacker-benedict ,