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Chemoimmunotherapy Is Associated With Tumor Downstaging in Urothelial Cancer

Neoadjuvant pembrolizumab plus gemcitabine with or without cisplatin led to high rates of downstaging to non–muscle invasive urothelial cancer in patients with muscle-invasive urothelial cancer, meeting the primary end points for both cohorts of the phase 1b/2 HCRN GU14-188 trial. ....

United States , Jason Brown , Novita Pharmaceuticals Inst , University Hospitals Seidman Cancer Center , Speaker Bureau , Bicycle Therapeutics , Jounce Therapeutics , Novita Pharmaceuticals , Urothelial Cancer , Non Muscle Invasive Urothelial Cancer , Hase 1b 2 Hcrn Gu14 188 Trial Nct02365766 ,