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MRI study looks for signs of Alzheimer's disease

Researchers led by radiologist Dr. Ilya Nasrallah, PhD, of the University of Pennsylvania studied the MRI scans of 454 hypertensive patients who were 50 years or older and completed a brain MRI at baseline and then at four-year follow-up in July 2016. Among the two patient groups, they compared hippocampal volume, measures of Alzheimer s disease regional atrophy, posterior cingulate cerebral blood flow, and mean fractional anisotropy (FA) in the cingulum bundle.
There is no consistent or clinically meaningful difference in magnetic resonance imaging biomarkers of Alzheimer s disease between intensive and standard blood pressure treatment, Nasrallah and colleagues wrote.
Vascular disease is a common comorbidity and may play a factor in initiating or accelerating hippocampal atrophy and mild cognitive impairment (MCI), characteristic biomarkers of Alzheimer s disease. Some studies have found that treating hypertension may reduce the incidence of Alzheimer s disease, but n ....

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PET scans show early link between heart disease, brain function

February 16, 2021 PET scans demonstrate that middle-aged individuals with early signs of cardiovascular disease also have reduced brain metabolism, according to researchers from Spain. The findings indicate that the early stages of Alzheimer s disease could begin years before dementia occurs.
Researchers with the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid used PET to examine over 500 individuals participating in the Progression of Early Subclinical Atherosclerosis (PESA) project. Directed by CNIC general director Dr. Valentin Fuster, PhD, the PESA study is following over 4,000 employees from Banco Santander in Spain to identify lifestyle and other risk factors that lead to atherosclerotic diseases. ....

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