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Since the COVID-19 vaccine was authorized for use in the United States, people with rheumatoid arthritis (RA) and their doctors have had questions about whether the shots are as effective if they take common medications to control their disease.
People on immune-suppressing medications were excluded from the clinical trials. It has been unclear whether the vaccine behaves the same in someone on these drugs as it does in the healthy people studied in the trials.
Now, answers are starting to emerge, and it appears those concerns may have been warranted. A study published May 25 in the
Annals of the Rheumatic Diseases found that up to one-third of people taking methotrexate failed to achieve an adequate immune response to the shot. ....

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