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New gene therapy model offers hope for X-linked sideroblastic anemia treatment

New gene therapy model offers hope for X-linked sideroblastic anemia treatment
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

United States , Carlo Castruccio Castracani , Stefano Rivella , Division Of Hematology , American Society Of Gene Cell Therapy , Clinical Research Study , Novel Model , X Linked Sideroblastic Anemia , Ring Sideroblasts , Severe Anemia , Iron Overload , Lentiviral Gene Transfer , American Society , Cell Therapy , Kwame Ohene Frempong Endowed Chair , Pediatric Hematology , Clinical Research Study Manager , Lentiviral Gene ,

Gene Therapy Model Brightens Outlook for X-Linked Anemia Cure

Gene Therapy Model Brightens Outlook for X-Linked Anemia Cure
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United States , Stefano Rivella , Carlo Castruccio Castracani , American Society Of Gene Cell Therapy , Clinical Research Study , Division Of Hematology , Novel Model , X Linked Sideroblastic Anemia , Ring Sideroblasts , Severe Anemia , Iron Overload , Lentiviral Gene Transfer , American Society , Cell Therapy , Kwame Ohene Frempong Endowed Chair , Pediatric Hematology , Clinical Research Study Manager ,

DSU Awards Graduate Research Initiative Grants

DSU Awards Graduate Research Initiative Grants
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Mark Hawkes , Brad Fowler , John Hastings , Gary Zhou , Chris Kreider , Bijay Shakya , Sunil Arora , Omar El Gayar , Adoption Of Technology In Consumer , College Of Business Information Systems , Mental Health Issues Due To Challenging , Beacom College Of Computer Cyber Sciences , Research Initiative At Dakota State University , Graduate Research Initiative , Dakota State University , Research Symposium , Information Systems , Experimental Assessment , Novel Model , Virtual Realities , Extraction Approach , Internet Of Vehicles Technology , Beacom College , Mental Health Issues Due , Attention Mechanism ,

Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there has long been evidence that the immune system is not completely incapable of responding to M. ulcerans infection. In particular, IL-1beta was recently shown to be present in BU lesions, and to be induced from M. ulcerans-exposed macrophages in a mycolactone-dependent manner. This has important implications for our understanding of BU, showing that mycolactone can act as the “second signal” for ....

United States , Western Australia , Le Bon , Scandj Rheumatol , Rheumatol Oxford , M Ulcerans Mycolactone Cytotoxicity , Pedrosaj Mycolactone , Waal Malefyt , Sarpong Duah , Rajko Reljic , Van Haver , Van Puyenbroeck , Thyet Mycolactone , Mycolactone Polyketide Synthases , Prof Pamela Small University Of Knoxville , Riverside Research Ethics Committee , Kennedy Institute Trustees , Wellcome Trust Investigator Award In Science , Streptomycin For Limited Buruli Ulcer Lesions , Prof Yoshito Kishi Harvard University , Lancet Glob Health , Dr Justice Boakye Appiah St George University London , West Africa , Immune Response , Buruli Ulcer , Wellcome Trust Investigator Award ,

79 Indian-American including some South Asian Teens Named Nation's Top Scientists

79 Indian-American including some South Asian Teens Named Nation's Top Scientists
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Ledgemont High School , New York , United States , Shaker High School , Hamilton High School , Sunset High School , Spring Valley High School , Manhasset High School , Palo Alto High School , Thomas Jefferson High School , Horace Greeley High School , Shorewood High School , Saratoga High School , South Sudan , Bethpage High School , West Senior High School , Plainedge High School , Nassau County , Hauppauge High School , Harker School , Nueva School , Mill River , Roslyn High School , Eleanor Roosevelt High School , Syosset High School , Herricks High School ,