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Drug for Arthritis may Treat Myocarditis in Cancer Patients

Drug for Arthritis may Treat Myocarditis in Cancer Patients
by Angela Mohan on
December 24, 2020 at 10:48 AM
Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center (VUMC).
Abatacept reduced the severity of myocarditis in a genetic mouse model study. This mouse model revealed the mechanisms for how the drug works.
Javid Moslehi, MD, director of Cardio-Oncology at Vanderbilt-Ingram Cancer Center, James Allison, PhD, executive director of the Immunotherapy Platform at MD Anderson Cancer Center, Spencer Wei, PhD, a former postdoctoral fellow at MD Anderson, and Justin Balko, PharmD, PhD, associate professor of Medicine and Pathology, Microbiology, and Immunology at VUMC and Vanderbilt-Ingram conceived the research project. ....

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Arthritis drug may be effective in treating immunotherapy-related heart complication

Arthritis drug may be effective in treating immunotherapy-related heart complication
A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in
Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center (VUMC).
The researchers demonstrated that the drug abatacept reduced the severity of myocarditis in a genetic mouse model study - responses that have also been observed in three human patients who were given the same drug after corticosteroid treatments failed to reduce heart muscle inflammation. The mouse model revealed the mechanisms for how the drug works. ....

France General , Joe Elie Salem , Doug Johnson , James Allison , Spencer Wei , Justin Balko , Emily Henderson , Javid Moslehi , Vanderbilt University Medical Center , Sorbonne University , Oncology At Vanderbilt Ingram Cancer Center , Md Anderson Cancer Center , Cancer Discovery , Vanderbilt Ingram Cancer Center , Cancer Center , Associate Professor , New England Journal , பிரான்ஸ் ஜநரல் , டக் ஜான்சன் , ஜேம்ஸ் அல்லிசன் , ஸ்பென்சர் வெய் , ஜஸ்டின் பால்கோ , எமிலி ஹென்டர்சன் , வாண்டர்பில்ட் பல்கலைக்கழகம் மருத்துவ மையம் , சோர்போன் பல்கலைக்கழகம் , புற்றுநோயியல் இல் வாண்டர்பில்ட் இஂக்ரம் புற்றுநோய் மையம் ,

Arthritis drug may treat immunotherapy-related heart complication

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A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in
Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center (VUMC).
The researchers demonstrated that the drug abatacept reduced the severity of myocarditis in a genetic mouse model study - responses that have also been observed in three human patients who were given the same drug after corticosteroid treatments failed to reduce heart muscle inflammation. The mouse model revealed the mechanisms for how the drug works. ....

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