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(Dân trí) - Thảo hẹn gặp My, không đánh ghen, không chửi bới, đề nghị hai người yêu nhau thì cứ đến với nhau. Nào ngờ, bồ nhí của chồng từ chối: "Em ngủ vớ
The Cas9 nuclease widely used for genome editing is derived from natural bacterial defense systems that protect against invading viruses. Cas9 is directed by RNA guides to cut matching viral DNA. Jiao et al. discovered that RNA guides can also originate from cellular RNAs unassociated with viral defense (see the Perspective by Abudayyeh and Gootenberg). They rendered this process programmable, linking the presence of virtually any RNA to cutting of matching DNA by Cas9. This capability is the basis of a new CRISPR diagnostic method developed by the authors that can detect many biomarkers at on...
8). The tracrRNA hybridizes to the “repeat” portion of each crRNA within the transcribed array. Host-derived RNase III then cleaves the formed RNA stem to generate a processed crRNA:tracrRNA duplex utilized by Cas9 ( 6). What remains unclear is whether crRNAs are confined to CRISPR-Cas loci or can be derived from elsewhere in the genome. Here, we show that crRNAs can be derived from host RNAs outside the CRISPR-Cas locus, inspiring a novel Cas9-based diagnostic platform that allows scalable detection of multiple biomarkers in a single test. Cellular RNAs bound to Cas9 from C. jejuni rese...
A hockey nut since his Toronto childhood, Devellano actually launched his bird-dogging career as an unpaid scout in 1967 when the Blues entered the NHL in its first expansion. Now, Jimmy was hoping Torrey would offer him a paying job to find talent for the team that soon would call it home on Hempstead Turnpike. Devellano: "We chatted for a long time that afternoon, right there on the street. I wound up with a firm promise to meet with Torrey and Chadwick in Toronto the following month. I had my foot in the door." Nobody could know it at the time but -- apart from Torrey -- Devellano would em...
The Roots - 'Do You Want More?!!!??!' deluxe reissue. CREDIT: Press The Roots have announced that they’re gearing up to reissue their acclaimed second album, ‘Do You Want More?!!!??!’. The deluxe re-release of the 1995 LP boasts multiple unreleased tracks, remixes, and alternate versions of songs, including a “Street Mix” version of ‘Silent Treatment’, which you can listen to below. The updated version of the much celebrated rap-jazz album includes four other remixes of ‘Silent Treatment’ which have never before been released digitally; two of these were done by The Roots...