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We are introducing PQ3, a groundbreaking cryptographic protocol for iMessage that advances the state of the art of end-to-end secure messaging. With compromise-resilient encryption and extensive defenses against even highly sophisticated quantum attacks, PQ3 provides protocol protections that surpass those in all other widely deployed messaging apps.
What are believed to be human remains from the Titan submersible that imploded with five passengers inside while exploring the wreckage of the Titanic will be brought to the U.S. for examination. “United States medical professionals will conduct a formal analysis of presumed human remains that have been carefully recovered within the wreckage at the site of the incident,” the U.S. Coast Guard ...
As readers of The Lancet Regional Health – Western Pacific, along with the fact that measles outbreaks have been warned of perfect storm of conditions for within 2022 by UNICEF and WHO, we pay a significant interest to the content of the paper entitled “Measles outbreak in the Philippines: Epidemiological and clinical characteristics of hospitalized children, 2016–2019” published earlier within the same journal.1,2 However, upon reproducing the results, we suspect that the authors has made several computational errors.
The Cas9 nuclease widely used for genome editing is derived from natural bacterial defense systems that protect against invading viruses. Cas9 is directed by RNA guides to cut matching viral DNA. Jiao et al. discovered that RNA guides can also originate from cellular RNAs unassociated with viral defense (see the Perspective by Abudayyeh and Gootenberg). They rendered this process programmable, linking the presence of virtually any RNA to cutting of matching DNA by Cas9. This capability is the basis of a new CRISPR diagnostic method developed by the authors that can detect many biomarkers at on...
8). The tracrRNA hybridizes to the “repeat” portion of each crRNA within the transcribed array. Host-derived RNase III then cleaves the formed RNA stem to generate a processed crRNA:tracrRNA duplex utilized by Cas9 ( 6). What remains unclear is whether crRNAs are confined to CRISPR-Cas loci or can be derived from elsewhere in the genome. Here, we show that crRNAs can be derived from host RNAs outside the CRISPR-Cas locus, inspiring a novel Cas9-based diagnostic platform that allows scalable detection of multiple biomarkers in a single test. Cellular RNAs bound to Cas9 from C. jejuni rese...