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Role of CRISPR-Cas12a visual biosensor in detection of SARS-CoV-2

A new study aimed to develop a novel CRISPR-Cas12a powered visual biosensor for the detection of SARS-CoV-2. ....

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CRISPR/Cas technology helped revolutionize diagnostics and gene therapy

CRISPR/Cas technology helped revolutionize diagnostics and gene therapy
Announcing a new article publication for
BIO Integration journal. In this mini review article the authors Meiyu Qiu and Pei Li from Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea summarize CRISPR/Cas-based Diagnostics and Gene Therapy.
Clustered regularly interspaced short palindromic repeats (CRISPR) technology, an easy, rapid, cost-effective, and precise gene-editing technique, has revolutionized diagnostics and gene therapy. Fast and accurate diagnosis of diseases is essential for point-of-care-testing (POCT) and specialized medical institutes.
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The CRISPR-associated (Cas) proteins system shed light on the new diagnostics methods at point-of-care (POC) owning to its advantages. In addition, CRISPR/Cas-based gene-editing technology has led to various breakthroughs in gene therapy. It has been employed in clinical trials for a variety ....

Taejon Gwangyoksi , South Korea , Republic Of Korea , Pei Li , Meiyu Qiu , Emily Henderson , Korea Advanced Institute Of Science , Korea Advanced Institute , Cas Based Diagnostics , Gene Therapy , Nex Vivo , Gene Editing , Palindromic Repeats , தெற்கு கொரியா , குடியரசு ஆஃப் கொரியா , பேய் லி , எமிலி ஹென்டர்சன் ,

Gene-cutting system may play second role as a genetic dimmer switch

Gene-cutting system may play second role as a genetic dimmer switch
In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 as a genetic dimmer switch for CRISPR-Cas9 genes. Its role of dialing down or dimming CRISPR-Cas9 activity may help scientists develop new ways to genetically engineer cells for research purposes.
A summary of the findings was published Jan. 8 in
Cell.
First identified in the genome of gut bacteria in 1987, CRISPR-Cas9 is a naturally occurring but unusual group of genes with a potential for cutting DNA sequences in other types of cells that was realized 25 years later. Its value in genetic engineering programmable gene alteration in living cells, including human cells was rapidly appreciated, and its widespread use as a genome editor in thousands of laboratories worldwide was recognized in the awarding of ....

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