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Molecular subtype of cancer preferentially affects people with Indigenous ancestry Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry " which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood. To deepen the understanding of the molecular determinants of the disease in this population, the authors conducted an integrative analysis of gene expre...

To deepen the understanding of the molecular determinants of the disease in this population, the authors conducted an integrative analysis of gene expression and DNA methylation in HCC developed by 74 Peruvian patients, including 39 adolescents and young adults. While genome-wide hypomethylation is considered as a paradigm in human HCCs, the analysis revealed that Peruvian tumors are associated with a global DNA hypermethylation. Remarkably, the development of this HCC subtype occurs in patients with one of the four Native American mitochondrial haplogroups A-D. Finally, integrative character...