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From the No. 1 draft pick wearing a custom suit to the classic white sneaker making a comeback - Vimarsana News

From the No. 1 draft pick wearing a custom suit to the classic white sneaker making a comeback

When it comes to fashion, we are all inspired by what we see; whether it be a well-dressed celebrity, a blow-your-mind catwalk presentation or even a super stylish every-day passerby. As fashion editors, we're moved by all of the above, and then some. We're exposed to under-the-radar labels; we get a first-hand look at collections months before they hit stores; we're tapped into brands with chic-yet-cheap offerings and we shop — a lot. To share our knowledge, FEMAIL brings you Style Swoon, a weekly series of the latest, greatest and on the verge. We hope this Friday series will serve as a b...

Striking Microgliosis in New APP Knock-in Mice - Vimarsana News

Striking Microgliosis in New APP Knock-in Mice

06 Feb 2021 A new APP knock-in mouse has hit the scene. Researchers led by Pascal Sanchez, Denali Therapeutics, San Francisco, California, described the details in a paper posted to bioRxiv on January 20. They humanized the Aβ sequence in the mouse APP gene and knocked in three familial Alzheimer’s disease mutations: Swedish, Arctic, and Austrian. TREM2 expression and cytokine concentrations spiked in brain tissue, microglia flocked to plaques, neurites swelled, and tau and neurofilament light collected in their cerebrospinal fluid. Notably, microglia surrounding plaques seemed distressedâ...