Fluxion's new fully packaged ion channel screening solution
A complete system for lead-to-answer screening in ion channel assays
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A complete system for lead-to-answer screening in ion channel assays
The Sutter Instrument NAN™ is a focusing nosepiece microscope designed for patch clamp electrophysiology or material science. Highly stable, adj
Discover how innovations in automated patch clamp technology have accelerated drug discovery
αO-Conotoxin GeXIVA is a 28 amino acid peptide derived from the venom of the marine snail Conus generalis. The presence of four cysteine residues in the structure of GeXIVA allows it to have three different disulfide isomers, that is, the globular, ribbon or bead isomer. All three isomers are active at α9α10 nicotinic acetylcholine receptors, with the bead isomer, GeXIVA[1,2], being the most potent and exhibiting analgesic activity in animal models of neuropathic pain. The original report of GeXIVA activity failed to observe any effect of the isomers on high voltage-activated (HVA) calcium ...