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Abstract Substitution for aspartic acid by glycine at position 614 in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 appears to facilitate rapid viral spread. The G614 strain and its recent variants are now the dominant circulating forms. We report here cryo-EM structures of a full-length G614 S trimer, which adopts three distinct prefusion conformations differing primarily by the position of one receptor-binding domain. A loop disordered in the D614 S trimer wedges between domains within a protomer in the G614 spike. This added interaction appears to prevent prematu...

9. Chung  AW, Kumar  MP, Arnold  KB,  et al.  Dissecting polyclonal vaccine-induced humoral immunity against HIV using systems serology.  10. Walsh  EE, Frenck  RW  Jr, Falsey  AR,  et al.  Safety and immunogenicity of two RNA-based Covid-19 vaccine candidates.  11. Widge  AT, Rouphael  NG, Jackson  LA,  et al; mRNA-1273 Study Group.  Durability of responses after SARS-CoV-2 mRNA-1273 vaccination.  12. Anderson  EJ, Rouphael ...

President Lawrence S. Bacow As a president twice, and adviser to many other university leaders, Lawrence S. Bacow says he often counsels them that their second year in office, after the honeymoon, is often the toughest. That was true for his predecessor, Drew Gilpin Faust, who set about making plans for Harvard’s future, only to run head-on into the Great Recession, a decimated endowment, and years of austerity and dreams deferred. She in turn reminded Bacow that the coronavirus’s surge during his second year overturned every aspect of the University’s academic life: not just finan...

AHarvard immunologist said current vaccines appear to be effective enough to end the pandemic, despite growing concerns that more infectious COVID-19

In this special edition of BU’s weekly COVID-19 report, The Brink asked Gloria Waters and Judy Platt to explain why variant sequencing is important and whether it will impact people at BU.