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Imbalances in folic acid and vitamin B12 can alter brain development in mice

Folate is a B vitamin and a necessary nutrient to prevent neural tube defects, such as spina bifida. Folic acid, a synthetic form of folate, has been added to vitamins, breakfast cereals and other products in the U.S. and more than 80 other countries to ensure pregnant women get adequate amounts. ....

United States , Davis School , Teodoro Bottiglieri , Zachary Schaaf , Noemi Cannizzaro , Ralph Green , Konstantinos Zarbalis , Shailaja Racherla , Davis Health , Baylor Scott White Research Institute , Nutrition Examination , Uc Davis School Of Medicine , Department Of Pathology , Developmental Disabilities Research Center , Human Development , University Of California , Drug Administration , Laboratory Medicine , National Institute For Mental Health , Communications Biology , National Health , National Institute For Child Health , Centers For Disease , Disease Control , Nutrition Examination Survey , Cerebral Cortex ,

New AI tool spotlights hidden cancers for better diagnosis

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation. ....

Daiwei David Zhang , Mingyao Li , Perelman School Of Medicine , National Institutes Of Health , University Of Pennsylvania School Medicine , University Of Pennsylvania , Pennsylvania School , Inferring Super Resolution Tissue Architecture , Perelman School , Digital Pathology , Hierarchical Vision Transformer , National Institutes , Artificial Intelligence ,

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice. ....

Lucas Adams , Davedh Fremont , Saravanan Raju , Herberts Gasser Professor At Washington University , Washington University School Of Medicine , University School , Washington University School , Viral Disease ,

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window. ....

Yan Wang , Jocelyn Duen Ya Jea , Pei Wen Chao , Department Of Pathology , Doctoral Fellowship For Biomedical Research , Baylor College Of Medicine , Em Foundation Pre , Drug Administration , Nature Biotechnology , Baylor College , Laising Yen , Biomedical Research , Facility Support Award , Gene Therapy , Ene Expression , Immune Response , Mammalian Cells , Small Molecules ,

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration. ....

United States , Reza Dana , Refractive Surgery Service At Mass Eye , American Journal , Mass Eye , Harvard Medical School Department , Refractive Surgery Service , Harvard Medical School , Fuchs Dystrophy , Ell Death , Endothelial Cell , Medical School ,