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Sleep-disordered breathing in cognitively unimpaired amyloid-positive individuals may exacerbate neurodegeneration in medial temporal lobe subregions

A new study investigated the link between SDB severity and the volume of medial temporal lobe (MTL) substructures. In addition, it also evaluated the association between SDB and MTL subregions volumes with episodic memory performance. ....

French National Institute Of Health , Sleep Disordered Breathing , Medial Temporal Lobe Atrophy , Cognitively Unimpaired Amyloid Positive Older , Image Credit , Cornu Ammonis , Medit Ageing European , French National Institute , Medical Research , Lzheimer 39s Disease , Sleep Apnea ,

Lymphoid depletion associated with suppressed APC function characterizes the lethality of COVID-19 in mice

Individuals who are immunocompromised are considered at higher risk for severe or longer disease with COVID-19. Understanding the systemic immune response is vital for research efforts to reduce its effects on multiple organs. ....

Kangwon Do , South Korea , United States , Soult Ukpyolsi , Lily Ramsey , Je Kyung Seong , College Of Biomedical Science , Kangwon National University , Korea Mouse Phenotyping Center , Seoul National University , American Journal , Jun Won Park , Biomedical Science , Covid 19 , Immune Response , Ouse Model , Ars Cov 2 ,

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD. ....

United States , Nature Medicine , Alzheimer 39s Disease ,

Environmental enrichment may reduce early accumulation of amyloid plaques in Alzheimer's mouse model

About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that could delay or prevent pathophysiological changes that occur with AD. ....

Gerd Kempermann , John Krystal , Megan Craig , German Center , Biological Psychiatry , Neurodegenerative Diseases , Mouse Model , Lzheimer 39s Disease ,

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates-;a telltale sign of Alzheimer's brain pathology-;never go on to develop Alzheimer's-associated dementias? ....

Bruna Bellaver , Danielle Ellis , Tharick Pascoal , University Of Pittsburgh School Medicine , Pittsburgh School , Lzheimer 39s Disease ,