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Researchers Identify New Mechanism: Cancer Hijacks Enzyme Substrate Motif Mutations

Researchers Identify New Mechanism: Cancer Hijacks Enzyme Substrate Motif Mutations
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Jianfeng Chen , Pengda Liu , Lineberger Comprehensive Cancer Center , Gillings School Of Public Health , Department Of Biochemistry , Department Of Biostatistics , Comprehensive Cancer Center , Experimental Medicine , Cancer Genome Atlas , New Mechanism , Xianming Tan , Gillings School , Public Health , Lineberger Comprehensive Cancer ,

Researchers discover gene that impacts the development of Ewing sarcoma in children

Researchers discover gene that impacts the development of Ewing sarcoma in children
Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children. They have also identified a compound that shows potential to block OTUD7A protein activity. The finding, by scientists at the University of North Carolina and the Lineberger Comprehensive Cancer Center, appeared online June 1, 2021, in
Advanced Science.
About 250 children and young adults are diagnosed with Ewing sarcoma each year in the U.S. About half of those diagnosed will ultimately succumb to the disease, pointing to the need for better therapies. ....

Lineberger Pengda Liu , Ian Davis , G Denman Hammond , Emily Henderson , School Of Medicine , Lineberger Comprehensive Cancer Center , Cancer Genetics Program , University Of North Carolina , Atomwise Inc , Eshelman School Of Pharmacy , North Carolina , Pengda Liu , Hammond Professor , Childhood Cancer , Biden Pediatric Cancer Moonshot , President Biden , Bone Cancer , Ewing Sarcoma , ஈயந் டேவிஸ் , எமிலி ஹென்டர்சன் , பள்ளி ஆஃப் மருந்து , லிநேபேர்கேற் விரிவான புற்றுநோய் மையம் , புற்றுநோய் ஜெநெடிக்ஸ் ப்ரோக்ர்யாம் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா , எஷேல்மன் பள்ளி ஆஃப் மருந்தகம் , வடக்கு கரோலினா ,

Researchers discover gene linked to bone cancer in children, ID potential novel therapy

UNC Lineberger researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children. They have also identified a compound that shows potential to block OTUD7A protein activity. Critical relationships between proteins contribute to the development of cancers such as Ewing sarcoma. So, it was a seminal discovery when the UNC researchers found that OTUD7A controls the cancer-causing fusion protein. ....

Lineberger Pengda Liu , Ian Davis , G Denman Hammond , School Of Medicine , Lineberger Comprehensive Cancer Center , Cancer Genetics Program , University Of North Carolina , Atomwise Inc , Eshelman School Of Pharmacy , North Carolina Researchers , North Carolina , Pengda Liu , Hammond Professor , Childhood Cancer , Biden Pediatric Cancer Moonshot , President Biden , Medicine Health , ஈயந் டேவிஸ் , பள்ளி ஆஃப் மருந்து , லிநேபேர்கேற் விரிவான புற்றுநோய் மையம் , புற்றுநோய் ஜெநெடிக்ஸ் ப்ரோக்ர்யாம் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா , எஷேல்மன் பள்ளி ஆஃப் மருந்தகம் , வடக்கு கரோலினா , குழந்தை பருவம் புற்றுநோய் , ப்ரெஸிடெஂட் பிடென் ,

Cancer Drug Shows Potential Against Pseudo SARS-CoV-2 in Lab Tests

Date Time
Cancer Drug Shows Potential Against Pseudo SARS-CoV-2 in Lab Tests
Despite the effectiveness of COVID-19 vaccines, treatments are still needed to combat this disease, which has killed millions of people and still kills thousands each day across the world. Scientists at the UNC School of Medicine conducted lab experiments showing how the cancer drug lenalidomide disrupts a cellular pathway in human cells so that pseudo-viruses derived from SARS-CoV-2 – the virus that causes COVID-19 – cannot enter cells to cause infection.
The research, published in a letter to the journal Signal Transduction and Targeted Therapy, shows the potential of an existing FDA-approved drug to help doctors treat the sickest COVID-19 patients. ....

United States , Siyuan Su , Pengda Liu , Lilly Wong , Guochun Jiang , Ying Wang , Jianfeng Chen , School Of Medicine , Guochun Jiang Lab , Breast Cancer Alliance Young Investigator Grant , Department Of Biochemistry , University Cancer Research Fund , Pengda Liu Lab , Lineberger Comprehensive Cancer Center , Gabrielle Angel Foundation Medical Research Award , Cure Center , V Scholar Research Grant , Signal Transduction , Targeted Therapy , Comprehensive Cancer Center , Angel Foundation Medical Research Award , Cancer Research , Qura Therapeutics , North Carolina , Chapel Hill Center , ஒன்றுபட்டது மாநிலங்களில் ,