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New Hyaluronic Acid Therapy Presents Chemical and Mechanical Cues Healing Injured Joint Cartilage

New Hyaluronic Acid Therapy Presents Chemical and Mechanical Cues Healing Injured Joint Cartilage
April 14, 2021
At joints surrounded by a sac of fluid (synovial joints), such as the knee, articular cartilage forms a thin layer that prevents bone from grinding against bone. Aging and intensive sports erodes or injures articular cartilage resulting in underlying bone to deteriorate, causing considerable pain.
Articular cartilage is composed of glossy and greyish hyaline that does not regenerate easily after injury. Therefore, once articular cartilage is injured, it is important to stabilize the surrounding remaining cartilage and bone, to prevent further deterioration of the joint.
Fortifying and reinforcing the affected cartilage with a surface biocompatible sealant material restores fluid pressure in the tissue and keeps the surface from further loss of fluid and tissue. ....

Jay-patel , Robert-mauck , Penn-medicine-mckay-orthopaedic-research-laboratory , Emory-university , University-of-pennsylvania , Mckay-lab , Perelman-school-of-medicine , Advanced-healthcare-materials , Damaged-articular-cartilage , Mediated-reinforcement , Perelman-school , Orthopaedic-surgery

Modified Nanoparticles Can Stop Osteoarthritis Development

PHILADELPHIA After a team of researchers showed that a certain enzyme's presence in cartilage increased significantly in people with osteoarthritis,. ....

University-of-pennsylvania , Pennsylvania , United-states , Philadelphia , Biang-jang , Zhiliang-cheng , Lesan-yan , Ahmad-amirshaghaghi , Yulong-wei , Lijun-luo , Andrew-tsourkas , Penn-medicine-mckay-orthopaedic-research-laboratory

New Biosealant Can Stabilize Cartilage, Promote Healing After Injury

New Biosealant Can Stabilize Cartilage, Promote Healing After Injury
Penn Medicine researchers showed that a new hyaluronic acid hydrogel system can reinforce and seal areas of injured cartilage in animal studies
Newswise PHILADELPHIA A new biosealant therapy may help to stabilize injuries that cause cartilage to break down, paving the way for a future fix or – even better – begin working right away with new cells to enhance healing, according to a new animal-based study by researchers at the Perelman School of Medicine at the University of Pennsylvania. Their research was published in
.
“Our research shows that using our hyaluronic acid hydrogel system at least temporarily stops cartilage degeneration that commonly occurs after injury and causes pain in joints,” said the study’s senior author, ....

University-of-pennsylvania , Pennsylvania , United-states , Philadelphia , Jamesl-carey , Edwardd-bonnevie , Lianem-miller , Kamiels-saleh , Jason-burdick , Claudia-loebel , Jay-patel , Robert-mauck

New biosealant therapy may help treat damaged cartilage tissue

New biosealant therapy may help treat damaged cartilage tissue
A new biosealant therapy may help to stabilize injuries that cause cartilage to break down, paving the way for a future fix or - even better - begin working right away with new cells to enhance healing, according to a new animal-based study by researchers at the Perelman School of Medicine at the University of Pennsylvania. Their research was published in
Advanced Healthcare Materials.
Our research shows that using our hyaluronic acid hydrogel system at least temporarily stops cartilage degeneration that commonly occurs after injury and causes pain in joints. In addition to pausing cartilage breakdown, we think that applying this therapy can present a surface that is sticky for cells, such as stem cells that are routinely injected into joints to counteract injury. This reinforcing hydrogel could actually synergize with those cells to create a long-term solution. ....

Jason-burdick , Jay-patel , Robert-mauck , Emily-henderson , Ventures-program , Emory-university , Mckay-lab , Perelman-school-of-medicine , Penn-health-tech , Penn-medicine-mckay-orthopaedic-research-laboratory , Penn-center , University-of-pennsylvania

New biosealant therapy might help stabilize injury caused by cartilage breakdown

New biosealant therapy might help stabilize injury caused by cartilage breakdown
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University-of-pennsylvania , Pennsylvania , United-states , Jason-burdick , Jay-patel , Robert-mauck , Ventures-program , Emory-university , Mckay-lab , Perelman-school-of-medicine , Penn-health-tech , Penn-medicine-mckay-orthopaedic-research-laboratory