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Oxford-AstraZeneca COVID vaccine induces cell spikes similar to SARS-CoV-2's Scientists from the University of Oxford and the University of Southampton report in the journal ACS Central Science that cells infected with the ChAdOx1 vaccine produce spike proteins on the cells similar to those produced by natural SARS-CoV-2 infection. Artist imaging of protein spike on the surface of cells exposed to the vaccine. Image Credit: University of Southampton The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which protrudes from the virus envelope, is the key stru...

Researchers discover a new monoclonal antibody that is effective against SARS-CoV-2 variants A new monoclonal antibody targets a particular region of the receptor-binding domain (RBD) on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This region is usually not accessible to immune cells,  which may be why it has broad neutralizing capabilities. With the coronavirus disease 2019 (COVID-19) pandemic continuing around the globe, new mutants of SARS-CoV-2 are emerging. These new variants are likely more infectious and can better evade our immune response. The SARS-CoV-2 spike...

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The S1 subunit has the receptor-binding domain (RBD) and the N-terminal domain (NTD). The RBD binds to the host angiotensin-converting enzyme 2 (ACE2) to infect host cells. Neutralizing an...