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New method to enhance images of the SARS-CoV-2 virus Researchers report a method of removing noise from high-resolution transmission electron microscopy images using probabilistic generative models. Electron microscopy (EM) is a technique used to see viruses and their infection processes, allowing us to see how it binds to cells and spreads through the body. Transmission electron microscopy (TEM) can provide high-resolution images at the nanometer scale, but these low-light images generally have an abundance of noise. Images of viruses often appear flat or 2-dimensional. Several noise reduct...

By analyzing the cryoEM structures of antibodies against the SARS-CoV-2 virus, researchers report that the neutralizing capabilities of two antibodies are not affected by new strains as these antibodies target regions of the virus away from the ACE2 binding regions.

Results from the latest round of the real-time assessment of community transmission study (REACT-1) study in England indicate that although coronavirus disease 2019 (COVID-19) cases have decreased, the number of hospitalizations remains high.

Researchers tested a variety of RNA concentration and extraction methods and assays to develop a protocol for testing SARS-CoV-2 in wastewater, which may help improve COVID-19 surveillance.

O-glycosylation of SARS-CoV-2 spike protein in insect and human cell lines Sites of O-glycosylation on the spike protein were near N-glycosites, suggesting O-glycans complement N-glycans' effect in immune shielding. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, has some characteristics that were not seen before in human coronaviruses, such as mutation on the receptor-binding domain (RBD) for high affinity to the human angiotensin-converting enzyme 2 (ACE2) and presence of a furin cleavage site between the two subunits of the spike protei...