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Plant breeding can help increase crop productivity, reduce human malnutrition

Plant breeding can help increase crop productivity, reduce human malnutrition
Your morning cereal or oatmeal. The bread on your sandwich. The corn chips for your snack, and the cookies for dessert. Not one would be possible with the humblest of ingredients: the seed.
Seeds such as wheat, rice, and corn directly provide about 70% of the calories eaten by people every day. And they ultimately provide nearly every morsel of food, either by providing feed for livestock or by being grown into fruits and vegetables. It s no overstatement to say that without seeds, civilization would be impossible.
But seeds need our help. They are under stress from climate change, and under pressure to feed a growing population. ....

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Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization
Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body s glucose levels, which is important for the development of metabolic diseases like diabetes.
In a recent study, published in
The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
In the study, Mukesh K. Jain, MD, senior author, Chief Academic Officer at UH, and the Ellery Sedgwick Jr. Chair & Distinguished Scientist, and his team set out to investigate the role of a gene called Kruppel-like factor 15 (KLF15) in skeletal muscle. The team utilized a mouse model with KLF15 specifically ....

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What are the changes in the physical phenotype of blood cells in COVID-19?

While primarily a respiratory illness, there are distinctive alterations in the type and number of blood cells in COVID-19. A new study by a team of researchers in Germany describes the nature of these changes. ....

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Immune profiling shows differences in COVID-19 and influenza pathologic pathways

Immune profiling shows differences in COVID-19 and influenza pathologic pathways
A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.
The development could lead to potential therapeutic approaches to coronavirus disease 2019 (COVID-19) – the illness caused by SARS-COV-2.
Studies have called into question the uniqueness of the inflammatory profile observed in cases of COVID-19.
Influenza is also a virus that causes severe pneumonia, and it is not yet clear how immune pathways in SARS-CoV-2 infection cause more severe disease than other viruses, says Andrea Cox and colleagues. ....

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Gene Therapies May Provide New Dimension in Treating Post-Traumatic Stress Disorder (PTSD)

Gene Therapies May Provide New Dimension in Treating Post-Traumatic Stress Disorder (PTSD)
by Karishma Abhishek on
January 31, 2021 at 9:43 AM
Eighteen specific, fixed positions on chromosomes (known as loci) associated with post-traumatic stress disorder (PTSD) are identified by researchers at the University of California San Diego, Veterans Affairs San Diego Healthcare System (VASDHS), Yale University, and West Haven VA, published in the journal
Nature Genetics.
PTSD, long been known to be heritable, is a serious mental disorder that can occur after exposure to extreme, life-threatening stress, with a lifetime prevalence of approximately 7 per cent (but much higher among veterans). Traumatic events affect more than half to three-quarters of Americans over their lifetime, but most do not develop PTSD. ....

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