Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy
Date Time Mitochondrial enzyme found to block cell death pathway points to new cancer treatment strategy The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) plays an important and previously unknown role in blocking a form of cell death called ferroptosis, according to a new study published today in Nature by researchers at The University of Texas MD Anderson Cancer Center. Preclinical findings suggest that targeting DHODH can restore ferroptosis-driven cell death, pointing to new therapeutic strategies that may be used to induce ferroptosis and inhibit tumor growth. “By understan...
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