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The World Health Organization has updated the list of antibiotic-resistant bacteria after seven years and categorized them into groups based on criticality.

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B was instead found to kill fungi primarily by forming extramembraneous sponge-like aggregates that extract ergosterol from lipid bilayers2–6. Here we show that rapid and selective extraction of fungal ergosterol can yield potent and renal-sparing polyene antifungals. Cholesterol extraction was found to drive the toxicity of amphotericin B to human ren...

Kasim Allel and colleagues systematically review published literature from low- and middle-income countries and meta-analyse data extracted from 109 articles to explore the impact of bloodstream infections caused by antibiotic-resistant bacteria.

Bacterial infections, such as pneumonia, neonatal sepsis, and gastrointestinal infections, are the leading causes of death among children worldwide

/PRNewswire/ -- The antifungal drugs market size reached USD 13.81 Billion in 2021 and is expected to register a CAGR of 3.6% during the forecast period,...