New drug shows promise against pancreatic, breast cancers
A study in A second study, published in the Journal of Experimental Medicine, shows the drug’s effectiveness against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Zhi-Ren Liu, a biology professor at Georgia State University, created ProAgio from a human protein to target the cell surface receptor integrin αVβ₃, which is expressed on cancer-associated fibroblasts. Fibroblasts are cells that generate collagen and other fibrous molecules which tumors can mobilize into service, creating a thick, physical barrier known ...