Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output
In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. Previously, Chen-Yu Zhang's group identified extracellular miRNA as a new form of cell-to-cell communication. They are among the first that r...