Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses
Host cell transmembrane protein MARCH8 targets lysine residues to inhibit SARS-CoV-2 and other viruses The search for effective inhibitors with therapeutic potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the shattering pandemic of coronavirus disease 2019 (COVID-19), has thrown up some surprising results. A new study, released as a preprint on the bioRxiv* server, deals with the inhibitory activity of a membrane protein that has broad-spectrum activity against multiple viruses, showing that this is due to its effect on cytoplasmic lysine re...