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Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenes


All data are presented as the Mean ± SD. The Student’s
t-test or the Pearson’s Chi-square test/Fisher’s exact test was utilized to analyze difference between groups with continuous variables or categorical variables, respectively. The Kaplan-Meier method and the Log rank test were applied for overall survival with chondrosarcoma patients. Univariate and multivariate analyses of clinicopathological factors, ZNF395 level and overall survival were performed using Cox regression model. Statistical analyses were performed using SPSS (SPSS, Chicago, IL, USA) and
P ....

Grand Island , United States , Pearson Chi Square , Lipofectamine Rnaimax Invitrogen , Bright Panel , Becton Dickinson , Cell Quest Software , Left Panel , Chondrosarcoma Cell , American Type Culture Collection , Applied Biosystems , Immobilon Western Chemiluminescent , Gentian Violet , Cell Apoptosis , Assay Kit , Protein Expression , Clinicopathological Factors , Independent Prognostic , Cox Regression Analysis , Prognostic Factors , Overall Survival , Chondrosarcoma Growth , மாபெரும் தீவு , ஒன்றுபட்டது மாநிலங்களில் , பியர்சன் சி சதுரம் , சரி குழு ,

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials


Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials
The importance of computational modeling in the prediction of the course of the ongoing coronavirus disease 2019 (COVID-19) pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.
The virus causing this pandemic is the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes an asymptomatic or mild infection in the vast majority, but spreads rapidly and extensively to produce a huge caseload in a relatively short period of time. This has led to overwhelming demands on healthcare services in many severely affected countries. ....

South Africa , South African , Liji Thomas , Protein Expression , Epitope Design , Coronavirus Disease Covid 19 , Ars Cov 2 , Spike Protein , Amino Acid , Computational Modeling , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , ப்ரோடீந் வெளிப்பாடு ,

Increased Collagen Type V α2 (COL5A2) in Colorectal Cancer is As


In the current study, DDR1 has been identified as a cancer-associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues.
29 As an important receptor, DDR1 can bind all types of collagens and could influence their signalling upon collagen stimulation.
30 It has been reported that the phosphorylation of DDR1 could activate the WNT/β-catenin and AKT/mTOR signaling to drive cancer cell metastasis and progression.
31,32 We observed that pY792 DDR1, the active form of DDR1, was upregulated by COL5A2 overexpression in HCT116 and SW620 cells (Figure 4D).
These observations indicate that
COL5A2 expression upregulates WNT/β-catenin and PI3K/mTOR signaling via binding DDR1 with phosphorylation and activation of this receptor, which might contribute to CRC tumorigenesis or progression. ....

United States , Kang Wei , Bittner Colon , Qiqun Tang , Dako Autostainer , Aperio Imagescope , Akt Ser , Microarray Datasets , Watanabe Colon , Kaiser Colon , G Kaiser Colon , American Joint Committee On Cancer , Fudan University Shanghai Medical College , Sino Biological Inc , Kangwei Century Co , Cell Bank , Proteintech Group , Research Ethics Committee Of Fudan University , Cell Signaling Technology , Fudan University , Shanghai Institutes For Biological Sciences , Muscle Invasive Bladder , Shanghai Institutes , Biological Sciences , Gibco Life Technologies , Hyclone Laboratories ,