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Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID

Background and Objectives Recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears exponential, leaving a tail of patients reporting various long COVID symptoms including unexplained fatigue/exertional intolerance and dysautonomic and sensory concerns. Indirect evidence links long COVID to incident polyneuropathy affecting the small-fiber (sensory/autonomic) axons.

Methods We analyzed cross-sectional and longitudinal data from patients with World Health Organization (WHO)-defined long COVID without prior neuropathy history or risks who were referred for peripheral neuropathy evaluations. We captured standardized symptoms, examinations, objective neurodiagnostic test results, and outcomes, tracking participants for 1.4 years on average.

Results Among 17 patients (mean age 43.3 years, 69% female, 94% Caucasian, and 19% Latino), 59% had ≥1 test interpretation confirming neuropathy. These included 63% (10/16) of skin biopsies, 17% (2/12) ....

Khosro Farhad , Yair Mina , Pedro Steven Buarque , Joseph Tornabene , Matthewp Wicklund , Sara Dehbashi , Yancy Seamans , Lisa Paul , Madeleinec Klein , Jennifer Curtin , Shibani Mukerji , Division Of Intramural Research , National Institutes Of Health , World Health Organization , Department Of Neurology Thomas Jefferson University , Objectives Recovery , Protocol Approvals , National Institutes , Intramural Research , Thomas Jefferson University , Pedro Steven Buarque De Macedo , Article Processing Charge ,