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The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia an...

Coway Airmega 250 air purifier tackles bigger spaces in smaller footprint Chris Davies - Apr 27, 2021, 8:00am CDT Air purifier specialist Coway has a new model just in time for pollen and allergy season, with the Airmega 250 promising more filtration in a smaller footprint. Slotting in-between the company’s small and stylish Airmega 150, and the larger Airmega 300, the ‘tweener also packs a HEPA filter capable of blocking viruses and bacteria. Hardly surprising, that’s something a lot of people are considering these days, given the current health crisis. Coway isn’...

Source: Windows Central We're approaching a point now where new PCIe 3.0 SSDs will be looked upon in a similar way to a new SATA SSD. As good as they may be, we've already hit the limits the technology can offer and started moving forward. As Intel finally starts supporting PCIe 4.0, you'd hope that we'll see more and more of the new generation going forward. Samsung already has a PCIe 4.0 SSD. The superb Samsung 980 Pro launched in 2020 and it's an absolute screamer, easily one of the best SSDs on the market today. The latest from the company, the Samsung 980, is perhaps a little confusing s...

520 MB/s Performance gains would always be mild, but what you don't see from the chart above are the capacities available and the respective pricing. SSDs continue to become better value with higher capacities at lower prices, and in that regard the 870 EVO certainly has the edge over the 860 EVO and 850 EVO before it. The 870 EVO is actually on par with the 870 QVO QLC SSD I reviewed in 2020 Samsung 870 EVO Source: Windows Central Without continually banging the same drum, performance is something you can make a fairly decent estimate of without running any tests. Nevertheless, what a manuf...