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Apolipoprotein E (
APOE) ε4 is the single most important genetic risk factor for cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking, drinking, diet, and physical activity also have impact on cognition. The goal of the study is to investigate whether the association between lifestyle and cognition varies by
APOE genotype among the oldest old.
Methods and findings
We used the cross-sectional data including 6,160 oldest old (aged 80 years old or older) from the genetic substudy of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) which is a national wide cohort study that began in 1998 with follow-up surveys every 2–3 years. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score less than 18. Healthy lifestyle profile was classified into 3 groups by a composite measure including smoking, alcohol consumption, dietary pattern, physical activity, and body weight. ....

South Korea , United Kingdom , Carol Brayne , Chinese Longitudinal Healthy Longevity Survey , Chinese Longitudinal Healthy Longevity , University Open Research Data Platform Website , Genomics Institute , National Natural Sciences Foundation Of China , University Of Cambridge , National Bureau Of Statistics China , Research In Genomic Epidemiology , Research Ethics Committees Of Peking University , Duke University , National Key Rd Program Of China , Mini Mental State Examination , Creative Commons Attribution License , Peking University Open Research Data Platform , National Key Rd Program , National Natural Sciences Foundation , Beijing Genomics Institute , Clinical Dementia Rating , Aging Research , Genomic Epidemiology , Observational Studies , Research Ethics Committees , Peking University ,